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Item number: Cay45397-10

An inhibitor of TNF-alpha, inhibits TNF-alpha-induced secretion of a SEAP reporter in HEK-Blue cells (IC50 = 27 nM), reduces paw TNF-alpha, IL-1beta, and IL-6 levels and swelling in a mouse model of alpha-collagen antibody-induced arthritis. SMILES:...

Keywords:	TNF-Inhibitor 2,...
Application:	TNF-alpha inhibitor
CAS	2074702-04-6
MW:	494.93 D

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TNF-alpha-IN-2

Item number: TGM-T36097-25mg

Description: TNF-alpha-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFalpha), exhibiting an IC50 of 25 nM in the HTRF assay. It induces conformational changes in the TNFalpha trimer upon binding, disrupting signaling when the trimer interacts with TNFR1. TNF-alpha-IN-2...

CAS	2074702-04-6
MW:	494.92 D

From 1,886.00€ *

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