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IWP-O1
IWP-O1

Item number: Cay38418-10

IWP-O1 is an inhibitor of porcupine (PORCN), an enzyme that catalyzes palmitoylation of Wnt proteins. It inhibits Wnt signaling in L-Wnt-STF cells (IC50 = 80 pM in a reporter assay) and phosphorylation of Dishevelled-2 (Dvl2) and Dvl3 in HeLa cells when used at a concentration of 1 µM. IWP-O1 (1 µM) enhances the...
Keywords: Inhibitor of Wnt Production-O1, 5-phenyl-N-(5-phenyl-2-pyridinyl)-4-(4-pyridinyl)-1H-1,2,3-triazole-1-acetamide
Application: PORCN inhibitor
CAS 2074607-48-8
MW: 432.5 D
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