Description: Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation. Target: Caspase, Beta Amyloid. Smiles:...

The saikosaponins have potent anti-inflammatory activity on mouse ear edema induced by the tumor promoter, phorbol myristate acetate. In cell culture studies, they have been found to induce differentiation without growth inhibition and apoptosis in B16 melanoma cells. Saikosaponin a was found to have antimutagenic...

Saikosaponin C is a saikosaponin that has been found in B. falactum and has anti-inflammatory and analgesic activities. It reduces basal production of prostaglandin E2 (PGE2, Cay-14010) in isolated rat peritoneal macrophages when used at a concentration of 100 µg/ml. Saikosaponin C (5 mg/kg per day) decreases acetic...