Description: Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-kappaB inhibitor and also specifically inhibits HDAC1 protein, but is inactive against other class I/II HDACs. Parthenolide has anti-inflammatory, anti-tumor, and anti-viral activities. Target: Autophagy, Mitophagy, HDAC,...

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 µg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-kappaB- and STAT-mediated anti-apoptotic gene transcription....

White to light green solid. Soluble in DMSO, ethanol or dichloromethane. Insoluble in water. Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines, At low concentrations acts as antioxidant reducing oxidative stress generated through the TCR signaling...

Sesquiterpene lactone and active ingredient of feverfew. Anti-inflammatory agent. Induces apoptosis and cell necrosis. Suppresses NF-kappaB activity. A MAP kinase inhibitor.

White to off-white powder. Soluble in DMSO, ethanol or chloroform. Chemical. CAS: 20554-84-1. Formula: C15H20O3. MW: 248.32. Synthetic. Anticancer and antiangiogenic compound. Induces apoptosis, cell cycle arrest and autophagy in various cancer cell lines. At low concentrations acts as antioxidant reducing oxidative...