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Azelaprag
Item number: Cay44644-1
An APJ agonist, inhibits forskolin-induced cAMP accumulation in CHO cells expressing human APJ (EC50 = 0.23 nM), increases stroke volume and heart rate and decreases systemic vascular resistance, indicating increased cardiac reserve, in ZSF1 obese rats in a model of diastolic dysfunction at 1 mg/kg, i.v.. SMILES:...
| Keywords: | AMG 986, BGE-105,... |
| Application: | APJ (apelin receptor) agonist |
| CAS | 2049980-18-7 |
| MW: | 523.61 D |
From 194.00€
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Azelaprag
Item number: TGM-T14390-10mg
Description: Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases. Target: Apelin receptor. Smiles: N(S([C@H]([C@H](C)C=1N=CC(C)=CN1)C)(=O)=O)C=2N(C(=NN2)C=3C=C(C)C=NC3)C4=C(OC)C=CC=C4OC. References: Burstein AH,...
| Keywords: | AMG 986 |
| CAS | 2049980-18-7 |
| MW: | 523.61 D |
From 101.00€
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