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Oritinib
Item number: Cay45042-1
Oritinib is an inhibitor of mutant EGFR. It selectively inhibits EGFRL858R, EGFRL858R/T790M, EGFRDelta746-750, and EGFRDelta746-750/T790M (IC50s = 0. 0. 1. and 0. nM, respectively) over wild-type EGFR (IC50 = 18 nM). In vivo, oritinib (2. 5, and 15 mg/kg) inhibits tumor growth in PC-9 and H1975 mouse xenograft...
| Keywords: | SH-1028, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-... |
| Application: | Mutant EGFR inhibitor |
| CAS | 2035089-28-0 |
| MW: | 539.68 D |
From 134.00€
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Oritinib
Item number: TGM-T60076-100mg
Description: Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (d746-750), EGFR (d746-750/T790M), respectively. Oritinib can be used in studies about the treatment of non-small cell lung cancer. Target: EGFR....
| Keywords: | SH-1028 |
| CAS | 2035089-28-0 |
| MW: | 539.67 D |
From 128.00€
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