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WNK463
Item number: TGM-T7017-100mg
Description: WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4). Target: Serine/threonin kinase. Smiles: CC(C)(C)NC(=O)c1cncn1C1CCN(CC1)c1ccc(cn1)-c1nnc(o1)C(F)(F)F. References: Yamada K, et al. Nat Chem Biol. 2016, 12(11):896-898.
| Application: | WNK1-4 inhibitor |
| CAS | 2012607-27-9 |
| MW: | 463.46 D |
From 72.00€
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WNK463
Item number: Cay37673-10
WNK463 is an inhibitor of WNK lysine-deficient protein kinase 1 (WNK1), WNK2, WNK3, and WNK4 (IC50s = 5, 1, 6, and 9 nM, respectively). It is selective for WNK1-4 over a panel of 442 kinases at 10 µM. In vivo, WNK463 (1, 3, and 10 mg/kg) decreases blood pressure, as well as increases urine output and urinary sodium...
| Keywords: | N-(1,1-dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]-1H-imidazole-5-carbox... |
| Application: | WNK1-4 inhibitor |
| CAS | 2012607-27-9 |
| MW: | 463.5 D |
From 108.00€
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