Description: GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 µM for full-length USP7, 0.43 µM for the USP7 catalytic domain, 20.3 µM for full-length USP43, and 0.23 µM for Ub-MDM2, respectively. Target: DUB. Smiles:...

GNE-6640 is an inhibitor of ubiquitin-specific protease 7 (USP7, IC50 = 0.75 µM). It is selective for USP7 over USP47 and USP5 (IC50s = 20.3 and >200 µM, respectively). GNE-6640 enhances ubiquitination of the USP7 substrate MDM2 in HCT116 colon cancer cells (IC50 = 0.23 µM) and reduces cell viability in a panel of...