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Y-33075
Item number: TGM-T13384-100mg
Description: Y-33075, a selective inhibitor of ROCK derived from Y-27632, exhibits greater potency than Y-27632 with an IC50 of 3.6 nM. Target: PKC. Smiles: C[C@@H](N)c1ccc(cc1)C(=O)Nc1ccnc2[nH]ccc12. References: Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated...
| Keywords: | Y 39983 |
| Application: | ROCK2 inhibitor |
| CAS | 199433-58-4 |
| MW: | 280.32 D |
From 112.00€
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Y-33075
Item number: Cay35108-1
Y-33075 is an inhibitor of Rho-associated kinase 2 (ROCK2, IC50 = 3.6 nM). It is selective for ROCK2 over PKC and calcium/calmodulin-dependent protein kinase II (CaMKII, IC50s = 420 and 810 nM, respectively). Topical application of Y-33075 (0.05% v/v) reduces intraocular pressure in rabbit and cynomolgus monkeys....
| Keywords: | RKI-983, SNJ-1656, Y-39983, 4-[(1R)-1-aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-benzamide |
| Application: | ROCK2 inhibitor |
| CAS | 199433-58-4 |
| MW: | 280.3 D |
From 107.00€
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