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Item number: TGM-T63534-100mg

Description: PPTN hydrochloride is a potent, high-affinity, competitive, and highly selective P2Y14 receptor antagonist (KB: 434 pM) with no agonist or antagonist activity at P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors, exhibiting anti-inflammatory and anti-immune effects. Target: P2Y Receptor. Smiles:...

Application:	P2Y14 receptor (GPR105) antagonist
CAS	1992047-65-0
MW:	511.96 D

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PPTN (hydrochloride)

Item number: Cay36854-1

PPTN is an antagonist of the purinergic P2Y14 receptor. It inhibits forskolin-induced cyclic AMP accumulation in C6 cells expressing human P2Y14 (EC50 = ~10 nM) but not CHO cells expressing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 at 1 µM. PPTN (5 µM) inhibits UDP-glucose-induced IL-1beta and chemokine (C-C...

Keywords:	4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid, monohydrochloride
Application:	P2Y14 receptor (GPR105) antagonist
CAS	1992047-65-0
MW:	512 D

From 60.00€ *

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