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GW311616A . HCl
Item number: AG-CR1-3632-M005
Solid. Soluble in DMSO or water. Potent, selective intracellular neutrophil elastase (NE, alpha-1-proteinase) inhibitor (by covalently binding to NE), Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC50 values of 22nM for HNE, >,100µ,M for trypsin, cathepsin G and...
| Keywords: | (3S,3aS,6aR)-3-Isopropyl-1-(methylsulfonyl)-4-((E)-4-(piperidin-1-yl)but-2-enoyl)hexahydropyrrolo[3,2-b]pyrrol-2(1H)-one |
| Application: | Potent selective intracellular neutrophil elastase (NE alpha-1-proteinase) inhibitor |
| CAS | 197890-44-1 |
| MW: | 434,0 D |
From 72.00€
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GW 311616A
Item number: Cay27957-1
GW 311616A is an inhibitor of neutrophil elastase (IC50 = 100 nM). It is selective for neutrophil elastase (IC50 = 22 nM for the human enzyme) over trypsin, cathepsin G, and plasmin (IC50s = >100 µM for all), as well as chymotrypsin and tissue plasminogen activator (IC50s = >3 µM for both), in cell-free assays. GW...
| Keywords: | (3S,3aS,6aR)-hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-buten-1-yl]-pyrrolo[3,2-b]py... |
| Application: | Neutrophil elastase inhibitor |
| CAS | 197890-44-1 |
| MW: | 434 D |
From 109.00€
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