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Item number: Cay14635-25

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of...

Keywords:	ChEMBL 273862, NSC 107124, (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Application:	Topoisomerase I inhibitor
CAS	19685-09-7
MW:	364.4 D

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