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SLF
Item number: Cay10007974-100
FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation. Synthetic ligand of FKBP (SLF) is a...
| Keywords: | Synthetic Ligand of FKBP, 1-(3,3-dimethyl-1,2-dioxopentyl)-(2S)-2-piperidinecarboxylic acid,... |
| Application: | FK-506 analog |
| CAS | 195513-96-3 |
| MW: | 524.7 D |
1,371.00€
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SLF
Item number: TGM-T13888-2mg
Description: SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 µM for FKBP51 and an IC50 of 0.22 µM for FKBP12. SLF can be used in the synthesis of PROTAC. Target: Others. Smiles: CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(N)c1. References: Kolos JM, et al....
| CAS | 195513-96-3 |
| MW: | 524.65 D |
94.00€
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