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Item number: Cay45142-1

MTX-211 is a dual inhibitor of PI3Kalpha and EGFR (IC50s = <100 nM for both). It reduces viability of 5637, EJ, and UM-UC-3 bladder cancer cells (IC50s = 1.075, 1.514, and 2.189 µM, respectively), an effect that can be partially inhibited by glutathione (GSH). MTX-211 also induces apoptosis, increases the levels of...

Keywords:	N-[2-chloro-5-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-3-pyridinyl]-methanesulfonamide
Application:	PI3Kalpha/EGFR dual inhibitor
CAS	1952236-05-3
MW:	478.32 D

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MTX-211

Item number: TGM-T4296-100mg

Description: MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases. Target: PI3K, EGFR. Smiles: CS(=O)(=O)Nc1cc(cnc1Cl)-c1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1. References: Small molecule inhibitors of egfr and pi3k. WO 2016100347 A2

Keywords:	MTX 211
CAS	1952236-05-3
MW:	478.33 D

From 55.00€ *

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