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Item number: Cay19081-1

Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers. CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM). It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell...

Keywords:	EKB-785, EKI-785, WAY-EKI-785, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide
Application:	Irreversible EGFR inhibitor
CAS	194423-06-8
MW:	381.2 D

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