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EAI045
Item number: TGM-T6824-100mg
Description: EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor. Target: EGFR. Smiles: Oc1ccc(F)cc1C(N1Cc2ccccc2C1=O)C(=O)Nc1nccs1. References: Jia Y, et al. Nature. 2016, 534(7605):129-32.
| Application: | EGFR inhibitor |
| CAS | 1942114-09-1 |
| MW: | 383.4 D |
From 37.00€
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EAI045
Item number: Cay19719-1
EAI045 is a potent and selective inhibitor of mutant EGF receptors (EGFRs, IC50s = 0.076, 0.049, 0.002, and 1.6 µM for recombinant EGFRL858R, EGFRT790M, EGFRL858R/T790M, and wild-type EGFR, respectively). It inhibits phosphorylation of EGFR in a concentration-dependent manner in H1975 cells. EAI045 (0.01-10 µM)...
| Keywords: | alpha-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-2H-isoindole-2-acetamide |
| Application: | EGFR inhibitor |
| CAS | 1942114-09-1 |
| MW: | 383.4 D |
From 53.00€
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