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YKL-05-099
Item number: TGM-T17271-100mg
Description: YKL-05-099 is an inhibitor of the salt-inducible kinase(SIK1 and SIK3 , IC50s: 10 and 30 nM, respectively). It has a slightly less potent SIK2-inhibitory (IC50:40 nM). Target: SIK. Smiles: COc1ccc(nc1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3OC)C3CCN(C)CC3)nc12)c1c(C)cccc1Cl. References: Sundberg TB, et al....
| Application: | SIK2 inhibitor |
| CAS | 1936529-65-5 |
| MW: | 600.11 D |
From 67.00€
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YKL-05-099
Item number: Cay36116-10
YKL-05-099 is an inhibitor of salt-inducible kinase 2 (SIK2, IC50 = 0.04 µM for the human enzyme). It is selective for SIK2 over a panel of 141 kinases at 1 µM but also inhibits 14 other kinases, including SIK3, Ephrin receptors, and Src. YKL-05-099 increases IL-10 production in zymosan A-induced isolated mouse bone...
| Keywords: | 3-(2-chloro-6-methylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-1-(5-methoxy-2-pyridinyl)-py... |
| Application: | SIK2 inhibitor |
| CAS | 1936529-65-5 |
| MW: | 600.1 D |
From 199.00€
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