An inhibitor of mutant EGFR, selective for EGFRL858R/T790M, EGFRT790M, and EGFR containing an exon 19 deletion (IC50s = 0.3, 0.5, and 0.5 nM, respectively) over wild-type EGFR (IC50 = 6 nM) and a panel of 258 kinases at 100 nM, inhibits BTK and Itk (IC50s = 2.1 and 0.4 nM, respectively), selectively inhibits the...

Description: ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. Target: Others. Smiles:...