Description: NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 µM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds...

NFATc1 inhibitor A04 is an inhibitor of nuclear factor of activated T cells c1 (NFATc1). It inhibits RANKL-induced nuclear translocation of NFATc1 in RAW 264.7 cells when used at concentrations of 1.5 or 2 µM. NFATc1 inhibitor A04 reduces RANKL-induced differentiation of RAW 264.7 cells into osteoclasts (IC50 = 1.57...