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YM976
Item number: TGM-T7954-10mg
Description: YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM). Target: PDE. Smiles: CCc1ccc2c(nc(=O)n(CC)c2n1)-c1cccc(Cl)c1. References: Aoki M , Kobayashi M , Ishikawa J , et al. A Novel Phosphodiesterase Type 4 Inhibitor, YM976 (4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with Little...
| Application: | PDE4 inhibitor |
| CAS | 191219-80-4 |
| MW: | 313.78 D |
From 43.00€
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YM-976
Item number: Cay29529-10
YM-976 is a phosphodiesterase 4 (PDE4) inhibitor (IC50 = 2.2 nM for the human peripheral leukocyte enzyme). It is selective for PDE4 over PDE1, -2, -3, and -5 (IC50s = >3 µM for all). YM-976 inhibits LPS-induced TNF-alpha production in human peripheral blood mononuclear cells (PBMCs). In vivo, YM-976 inhibits...
| Keywords: | 4-(3-chlorophenyl)-1,7-diethyl-pyrido[2,3-d]pyrimidin-2(1H)-one |
| Application: | PDE4 inhibitor |
| CAS | 191219-80-4 |
| MW: | 313.8 D |
From 128.00€
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