Tegaserod (maleate) is a potent agonist of the serotonin 4 receptor (5-HT4, Ki = 3.9-31 nM). As 5-HT4 receptors are associated with cholinergic nerves lining the colon, tegaserod (maleate) stimulates colonic motility and transit in vivo, in both healthy and diseased gastrointestinal tracts. However, it lacks...

Description: Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis for managing irritable bowel syndrome and constipation. It was the only drug approved by the United States Food and Drug Administration for relieving abdominal discomfort, bloating, and constipation associated with irritable...