Description: SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice. Target: Autophagy. Smiles: COc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1OC. References: Ren H, Bakas NA, Vamos M, et al. Design, Synthesis, and...

SBP-7455 is a dual inhibitor of unc-51-like autophagy activating kinase 1 (ULK1) and ULK2 (IC50s = 13 and 476 nM, respectively, for the recombinant human enzymes in cell-free assays). It inhibits increases in autophagic flux and induces apoptosis in serum-deprived MDA-MB-468 breast cancer cells when used at a...