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MSC2530818
Item number: TGM-TQ0266-100mg
Description: MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM). Target: CDK. Smiles: Cc1n[nH]c2ncc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1. References: Czodrowski P, et al. Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by...
| Application: | CDK8 inhibitor |
| CAS | 1883423-59-3 |
| MW: | 340.81 D |
From 60.00€
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MSC2530818
Item number: Cay29669-1
MSC2530818 is an orally bioavailable cyclin-dependent kinase 8 (Cdk8) inhibitor (IC50 = 2.6 nM). It is selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit glycogen synthase kinase 3alpha (GSK3alpha, IC50 = 691 nM). MSC2530818 inhibits STAT1 phosphorylation in SW620 colorectal cancer cells with an...
| Keywords: | [(2S)-2-(4-chlorophenyl)-1-pyrrolidinyl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone |
| Application: | CDK8 inhibitor |
| CAS | 1883423-59-3 |
| MW: | 340.8 D |
From 100.00€
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