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CXCR2-IN-1
Item number: TGM-T10905-100mg
Description: CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent. Target: CXCR. Smiles: CN1CCC(CC1)S(=O)(=O)c1c(Cl)ccc(NC(=O)Nc2cccc(F)c2Cl)c1O. References: Xu H, et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating...
| CAS | 1873376-49-8 |
| MW: | 476.35 D |
From 72.00€
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CXCR2-IN-1
Item number: Cay28426-1
CXCR2-IN-1 is a chemokine (C-X-C motif) receptor 2 (CXCR2) antagonist (IC50 = 0.501 nM in a reporter assay). It inhibits chemotaxis of isolated human neutrophils induced by chemokine (C-X-C motif) ligand 1 (CXCL1, IC50 = 79.4 nM). In vivo, CXCR2-IN-1 (100 mg/kg) inhibits forebrain lesion formation in a mouse model...
| Keywords: | CXCR2 Inhibitor 1, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-urea |
| Application: | CXCR2 antagonist |
| CAS | 1873376-49-8 |
| MW: | 476.3 D |
90.00€
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