6 products were found matching "186692-46-6"!

Potent and selective inhibitor of CDKs, More potent than olomoucine, Inhibits CDK1/cyclin B kinase (IC50 = 450 nM) , CDK2 (IC50 = 700 nM) and CDK5/p35 (IC50 = 160 nM), Inhibits M phase promoting factor (MPF) kinase activity, Arrests human fibroblasts in G1 phase, Antitumor compound, Activates the mitogen-activated...

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM. It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values...

Soluble in DMSO or ethanol. Slightly soluble in water. Stock solutions can be made up to 10 mM in DMSO. Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Pyridoxal kinase (PDXK) inhibitor. Triggers cell apoptotic cell death. Down-regulates Mcl-1 and MYCN. Anticancer...

Roscovitine is an inhibitor of CDKs (1, 2, 5, 7, 9, 12) and L-type Ca2+ channels, it exhibits anti-inflammatory and anticancer activities. Roscovitine resolves neutrophil-driven inflammation. In B-cell lymphoma cells, roscovitine induces cell cycle arrest and apoptosis and inhibits proliferation.

Analog of Olomoucine, formerly Cat. No. O-3590, but more potent as an inhibitor of p34cdc2 (IC50=0.2 uM). Also inhibits p33cdk2 and p33cdk5. Solubility: Prepare initial stock solutions in DMSO (soluble at 200mg/ml) or ethanol (soluble at 200mg/ml) for in vitro use, solubility in water is low, Melting Point:...

Description: Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50=0.1 µM). Seliciclib also inhibits Cdk7/cyclin H, Cdk5/p35 and Cdc2/cyclin B (IC50=0.49/0.16/0.65 µM). Seliciclib has antitumor activity. Target: CDK. Smiles: CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1. References: Meijer L, et al....