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Item number: TGM-T6258-10mg

Description: Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3. Target: Apoptosis, Endothelin Receptor. Smiles: COc1nc(C)cnc1NS(=O)(=O)c1cccnc1-c1ccc(cc1)-c1nnco1. References: Morris CD, et al. Br J Cancer, 2005, 92(12), 2148-2152.

Keywords:	ZD4054
Application:	Targets endothelin receptor type A (EDNRA)
CAS	186497-07-4
MW:	424.43 D

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Zibotentan

Item number: Cay23702-1

Zibotentan is a selective antagonist of the endothelin (ET) receptor type A (IC50s = 21 and >10,000 nM for human recombinant ETA and ETB, respectively). It inhibits growth of HEY, OVCA 433, SKOV3, and A2780 cells induced by endothelin 1 (ET-1, Cay-24127) in vitro. Zibotentan reduces ET-1-induced expression of MMP-2,...

Keywords:	ZD 4054, N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide
Application:	Antineoplastic, endothelin receptor type A antagonist
CAS	186497-07-4
MW:	424.4 D

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