Description: Alisol B may be a potential novel therapeutic molecule for bone disorders through targeting the differentiation of osteoclasts as well as their functions. Alisol B also inhibited RANKL-induced expression of NFATc1 and c-Fos, which are key transcription factors for osteoclastogenesis. Target: RANKL/RANK....

Alisol B is a triterpene that has been found in A. orientale and has diverse biological activities. It increases the number of LC3 puncta, a marker of autophagy, as well as induces cell cycle arrest at the G1 phase and apoptosis, in MCF-7 breast cancer cells when used at a concentration of 30 µM. Alisol B (0.5-5 µM)...