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CB-5339
Item number: Cay46233-10
CB-5339 is an inhibitor of the AAA-ATPase p97, also known as valosin-containing protein (VCP, IC50 = 9 nM), and a derivative of CB-5083 (Cay-19311). It inhibits phosphodiesterase 6C (PDE6C) and accumulates in rat retina to a lesser extent than CB-5083. CB-5339 inhibits the growth of 16 primary acute myeloid leukemia...
| Keywords: | 2-methyl-1-[5,6,7,8-tetrahydro-4-[(phenylmethyl)amino]pyrido[2,3-d]pyrimidin-2-yl]-1H-indole-4-carboxamide |
| Application: | ATPase p97/VCP inhibitor |
| CAS | 1863952-15-1 |
| MW: | 412.5 D |
From 105.00€
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CB-5339
Item number: TGM-T60193-100mg
Description: p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1]. Target: p97. Smiles: CC=1N(C=2C(=C(C(N)=O)C=CC2)C1)C3=NC(NCC4=CC=CC=C4)=C5C(N3)=NCCC5. References: David Wustrow, et al. FUSED PYRIMIDINE SASINHIBIT ORSOF p97 COMPLEX. WO2015109285A1.
| CAS | 1863952-15-1 |
| MW: | 412.49 D |
From 48.00€
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