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Item number: Cay21425-1

DK-AH 269 blocks hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (IC50 = 0.62 µM in mouse sinoatrial node cells). DK-AH 269 slows heart rate by decreasing the spontaneous firing rate of the sinoatrial node in the heart. Using telemetric ECG recordings in mice, it reduced heart rate in a...

Keywords:	Cilobradine,...
Application:	HCN channel blocker
CAS	186097-54-1
MW:	519.1 D

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Cilobradine hydrochloride

Item number: TGM-T10813-100mg

Description: Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels. Target: HCN Channel. Smiles: Cl.COc1ccc(CCN2CCC[C@H](CN3CCc4cc(OC)c(OC)cc4CC3=O)C2)cc1OC. References: Cheng L, et al. Molecular mapping of the binding site for a...

Keywords:	DK-AH 269
CAS	186097-54-1
MW:	519.07 D

From 36.00€ *

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