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QC6352
Item number: Cay26231-1
A KDM4 inhibitor, selective for KDM4A, KDM4B, KDM4C, and KDM4D (IC50s = 104, 56, 35, and 104 nM, respectively) over KDM2B, KDM3A, KDM3B, KDM6B, and PHF8 (IC50s = >4,000 nM for all) but does inhibit KDM5B (IC50 = 750 nM), increases H3K36Me3 levels in KYSE-150 cells (EC50 = 1.3 nM), reduces the proliferation of...
| Keywords: | 3-[[[(1R)-1,2,3,4-tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-4-pyridinecarboxylic acid |
| Application: | KDM4 inhibitor |
| CAS | 1851373-36-8 |
| MW: | 387.47 D |
From 186.00€
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QC6352
Item number: TGM-T16700-100mg
Description: QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM). Target: Histone Demethylase. Smiles: CN(c1ccccc1)c1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1. References: Chen YK, et al. Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett. 2017 Jul 27,8(8):869-874.
| CAS | 1851373-36-8 |
| MW: | 387.47 D |
From 410.00€
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