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Item number: TGM-T16860-100mg

Description: SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 µM). Target: Neurotensin Receptor. Smiles: COc1ccccc1C1CCN(CC1)c1nc(nc2ccc(cc12)N(C)CCO)C1(F)CC1. References: Pinkerton AB, et al. Discovery of beta-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin...

Application:	beta-arrestin-biased positive allosteric NTSR1 modulator
CAS	1849603-72-0
MW:	450.55 D

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SBI-553

Item number: Cay36782-10

SBI-553 is a beta-arrestin-biased positive allosteric modulator (PAM) of neurotensin receptor 1 (NTSR1). It binds to NSTR1 and increases neurotensin-1 affinity for NSTR1 in HEK293 cells expressing the human receptor when used at concentrations ranging from 0.01 to 10 µM. SBI-553 (0.03-30 µM) induces beta-arrestin...

Keywords:	2-[[2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)-1-piperidinyl]-6-quinazolinyl]methylamino]-ethanol
Application:	beta-arrestin-biased positive allosteric NTSR1 modulator
CAS	1849603-72-0
MW:	450.6 D

From 40.00€ *

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