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Item number: Cay42500-1

PF-06821497 is an enhancer of zeste homolog 2 (EZH2) inhibitor (Ki = <0. nM for EZH2Y641N). It is selective for EZH2 over a panel of 14 methyltransferases, 40 kinases, and 79 additional targets at 10 µM but does bind to EZH1 (Ki = 70 nM). PF-06821497 reduces trimethylation of lysine 27 on histone H3 (H3K27Me3) in,...

Keywords:	Mevrometostat,...
Application:	EZH2 inhibitor, antineoplastic, histone methyltransferase inhibitor
CAS	1844849-10-0
MW:	467.34 D

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