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Item number: Cay18113-500

YM-53601 is a squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively). It inhibits cholesterol biosynthesis in rats (ED50 = 32 mg/kg). YM-53601 dose-dependently reduces plasma triglyceride and non-HDL cholesterol levels in hamsters fed both normal and high-fat diets....

Keywords:	2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride
Application:	Squalene synthase inhibitor
CAS	182959-33-7
MW:	372.9 D

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YM-53601

Item number: TGM-T26345-1mg

Description: YM-53601 is a squalene synthase activity inhibitor that acts by lowering cholesterol as well as triglycerides. Target: Others. Smiles: Cl.F\C(COc1ccc2c(c1)[nH]c1ccccc21)=C1\CN2CCC1CC2. References: Alarcon VB, Marikawa Y. Statins inhibit blastocyst formation by preventing geranylgeranylation. Mol Hum...

Keywords:	YM53601
Application:	Squalene synthase inhibitor
CAS	182959-33-7
MW:	372.86 D

161.00€ *

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