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GSK864
Item number: Cay18762-1
GSK864 is an allosteric inhibitor of mutant isocitrate dehydrogenase 1 (IDH1, IC50s = 9, 15, and 17 nM for IDH1 mutants R132C, R132H, and R132G, respectively). It is moderately selective for mutant IDH1 over wild-type IDH1 and IDH2 mutants/wild-type. GSK864 causes a dose-dependent reduction in 2-hydroxyglutarate and...
| Keywords: | (S)-1-(4-fluorobenzyl)-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo... |
| Application: | IDH1 inhibitor |
| CAS | 1816331-66-4 |
| MW: | 558.6 D |
From 58.00€
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GSK864
Item number: TGM-T15442-10mg
Description: GSK864 is an IDH1 mutant inhibitor that inhibits IDH1 mutants R132C, R132H, and R132G, and is used in the study of cardiovascular and oncology diseases. Target: Dehydrogenase. Smiles: COc1c(C)cc(NC(=O)c2nn(Cc3ccc(F)cc3)c3c2CN(C[C@]3(C)C(N)=O)C(=O)c2ccc[nH]2)cc1C. References: Okoye-Okafor UC, et al. New...
| Keywords: | GSK-864, GSK 864 |
| Application: | IDH1 inhibitor |
| CAS | 1816331-66-4 |
| MW: | 558.6 D |
From 65.00€
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