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CCG215022
Item number: TGM-T3498-100mg
Description: CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 µM for GRK2, 0.38±0.06 µM for GRK5, and 3.9±1 µM for GRK1. Target: PKA, GRK. Smiles: CC1=C(C(NC(=O)N1)c1ccc(F)c(c1)C(=O)NCc1ccccn1)C(=O)Nc1ccc2[nH]ncc2c1. References: Homan KT, et al. Crystal Structure of G...
| Application: | GRK inhibitor |
| CAS | 1813527-81-9 |
| MW: | 499.5 D |
From 97.00€
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CCG-215022
Item number: Cay31120-1
CCG-215022 is a G protein-coupled receptor kinase (GRK) inhibitor (IC50s = 3.9, 0.15, and 0.38 µM for GRK1, GRK2, and GRK5, respectively). It is selective for GRKs over protein kinase A (PKA, IC50 = 120 µM). CCG-215022 (500 nM) increases contractility in isoproterenol-stimulated isolated mouse cardiomyocytes. It...
| Keywords: | 4-[4-fluoro-3-[[(2-pyridinylmethyl)amino]carbonyl]phenyl]-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidine... |
| Application: | GRK inhibitor |
| CAS | 1813527-81-9 |
| MW: | 499.5 D |
From 61.00€
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