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Item number: Cay30931-5

ONC212 is an agonist of the orphan G protein-coupled receptor GPR132 (EC50 = ~400 nM in a PathHunter(R) beta-arrestin assay). It inhibits cell growth in a panel of 62 human leukemia cell lines, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), and hairy...

Keywords:	2,4,6,7,8,9-hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
Application:	GPR132 agonist
CAS	1807861-48-8
MW:	440.5 D

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ONC212

Item number: TGM-T7398-100mg

Description: ONC212 [a fluorinated-ONC201 analogue] is a selective GPR132 agonist. Target: Apoptosis, GPR. Smiles: FC(F)(F)c1ccc(CN2C3=NCCN3C3=C(CN(Cc4ccccc4)CC3)C2=O)cc1. References: Nii T, Prabhu VV, Ruvolo V,et al.Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response...

Application:	GPR132 agonist
CAS	1807861-48-8
MW:	440.46 D

From 42.00€ *

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