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Samuraciclib hydrochloride
Item number: TGM-T10898-100mg
Description: Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold higher than CDK1, CDK2 (IC50 is 578 nM), CDK5 and CDK9 respectively. Samuraciclib...
| Keywords: | CT7001 hydrochloride, ICEC0942 hydrochloride |
| CAS | 1805789-54-1 |
| MW: | 430.97 D |
From 109.00€
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ICEC0942 (hydrochloride)
Item number: Cay30997-1
ICEC0942 is a cyclin-dependent kinase 7 (Cdk7) inhibitor (IC50 = 0.04 µM). It is selective for Cdk7 over Cdk1, -2, -4, -5, -6, and -9 (IC50s = 1.8, 0.62, 49, 9.4, 34, and 1.2 µM, respectively). ICEC0942 induces cell cycle arrest at the G2/M phase and apoptosis in HCT116 cells when used at concentrations of 1 and 10...
| Keywords: | (3R,4R)-4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-3-piperidinol,... |
| Application: | Cdk7 inhibitor |
| CAS | 1805789-54-1 |
| MW: | 431 D |
From 72.00€
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