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PRN1371
Item number: TGM-TQ0015-100mg
Description: PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R). Target: c-Fms, CSF-1R, FGFR. Smiles: CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1. References: Brameld KA, et al. Discovery of the Irreversible Covalent FGFR...
| Application: | Irreversible pan-FGFR inhibitor |
| CAS | 1802929-43-6 |
| MW: | 561.46 D |
From 74.00€
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PRN-1371
Item number: Cay33787-1
PRN-1371 is an irreversible covalent pan-FGFR inhibitor (IC50s = 0.7, 1.3, 4.4, and 19.3 nM for FGFR-1, -2, -3, and -4, respectively). It is selective for FGFR over VEGFR2 (IC50 = 705 nM) and a panel of 250 kinases (IC50s = >1 µM for all) but does inhibit colony stimulating factor 1 receptor (CSF1R) activity by...
| Keywords: | 6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]propyl]-pyrido[2,3-d]pyri... |
| Application: | Irreversible pan-FGFR inhibitor |
| CAS | 1802929-43-6 |
| MW: | 561.5 D |
From 96.00€
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