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SHP099
Item number: TGM-T3564-100mg
Description: SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 µM and p-ERK modulation in cells IC50 = 0.250 µM). SHP099 shows dose-dependent pathway inhibition and antitumor activity in xenograft models. Target: Phosphatase, PERK....
| Keywords: | SHP-099, SHP099 free base, SHP 099 |
| Application: | SHP2 inhibitor |
| CAS | 1801747-42-1 |
| MW: | 352.26 D |
From 31.00€
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SHP099
Item number: Cay20000-1
SHP099 is an orally bioavailable inhibitor of SHP2, a non-receptor protein tyrosine phosphatase (IC50 = 71 nM). It stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and...
| Keywords: | 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine |
| Application: | SHP2 inhibitor |
| CAS | 1801747-42-1 |
| MW: | 352.3 D |
From 61.00€
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