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Item number: Cay46299-10

E-7386 is an inhibitor of the protein-protein interaction between beta-catenin and CREB-binding protein (CBP). It inhibits reporter gene expression induced by beta-catenin in ECC10 gastric small cell carcinoma cells that express mutant adenomatous polyposis coli and in HEK293 cells (APC, IC50s = 14.7 and 48.4 nM,...

Keywords:	(6S,9aS)-8-[[6-[3-(4-ethyl-1-piperazinyl)-1-azetidinyl]-2-pyridinyl]methyl]-6-[(2-fluoro-4-hydroxyphenyl)methyl]hexahydro-...
Application:	Beta-catenin-CBP protein-protein interaction inhibitor
CAS	1799824-08-0
MW:	725.87 D

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E-7386

Item number: TGM-T11136-100mg

Description: E-7386 is an oral active CBP/ -catenin modulator. Target: Epigenetic Reader Domain. Smiles: [H][C@]12CN(Cc3cccc(n3)N3CC(C3)N3CCN(CC)CC3)C(=O)[C@H](Cc3ccc(O)cc3F)N1C(=O)CN(CC=C)N2C(=O)NCc1ccccc1. References: Yusaku Hori, et al. E7386, an orally active CBP/beta-catenin modulator, induces T cells...

Keywords:	E7386
CAS	1799824-08-0
MW:	725.85 D

From 84.00€ *

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