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dBET1
Item number: Cay18044-1
dBET1 is a hybrid molecule that combines (+)-JQ1 (Cay-11187) and thalidomide (Cay-14610). The JQ1 portion facilitates binding of dBET1 to the bromodomains of BET family transcriptional activators. The thalidomide moiety drives proteasomal degradation, as phthalimides bind cereblon to create a substrate recognition...
| Keywords: | (6S)-4-(4-chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]but... |
| Application: | Cereblon-dependent BET protein degradation |
| CAS | 1799711-21-9 |
| MW: | 785.3 D |
From 60.00€
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dBET1
Item number: BPS-82021
dBET1 is a PROTAC compound comprised of BET bromodomain antagonist (+)-JQ1 linked to a cereblon E3 ubiquitin ligase ligand.
| Application: | Protac(R) reagent |
| CAS | 1799711-21-9 |
| MW: | 785,3 D |
1,827.00€
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