NSC 23005 is a small molecule inhibitor of p18, as determined by an in silico screen. It promotes expansion of murine and human hematopoietic stem cells (HSCs) with an ED50 value of 5.21 nM in a single-cell in vitro culture assay using isolated murine bone marrow cells. NSC 23005 increases the number of long-term...

Description: NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) that promotes Hematopoietic stem cells (HSCs) expansion in both murine and human models. Target: CDK. Smiles: C1CCC(CC1)NS(=O)(=O)c1ccc(cc1)C(=O)[O-].[Na+]. References: Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors...