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Item number: TGM-T10639-10mg

Description: C-021 dihydrochloride is a potent CCR4 antagonist that effectively inhibits functional chemotaxis in humans and mice, with IC50 values of 140 nM and 39 nM, respectively. Target: CCR. Smiles: Cl.Cl.COc1cc2nc(nc(NC3CCCCCC3)c2cc1OC)N1CCC(CC1)N1CCCCC1. References: Yokoyama K, et al. Potent and orally...

CAS	1784252-84-1
MW:	540.57 D

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CCR4 Antagonist (hydrochloride)

Item number: Cay21885-1

Chemokine (C-C motif) receptor 4 (CCR4) antagonist is an antagonist of CCR4. It inhibits activation of CCR4 by chemokine (C-C motif) ligand 22 (CCL22) in a [35S]GTPgammaS assay and also inhibits chemotaxis in human and mouse CCR4-expressing B300-19 cells (IC50s = 18, 140, and 39 nM, respectively). CCR4 antagonist...

Keywords:	2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine, dihydrochloride
Application:	C-C chemokine receptor type 4 antagonist
CAS	1784252-84-1
MW:	540.6 D

From 81.00€ *

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