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PF-04859989 (hydrochloride)
Item number: Cay31383-1
PF-04859989 is an inhibitor of kynurenine aminotransferase II (KAT II, IC50s = 0.032 and 0.263 µM for human and rat recombinant enzymes, respectively). It is selective for KAT II over KAT I, -III, and -IV (IC50s = 21.6, 107, and >50 µM, respectively). In vivo, PF-04859989 (10 mg/kg, s.c.) reduces basal striatum,...
| Keywords: | (3S)-3-amino-3,4-dihydro-1-hydroxy-2(1H)-quinolinone, monohydrochloride |
| Application: | KAT II (kynurenine aminotransferase II) inhibitor |
| CAS | 177943-33-8 |
| MW: | 214.7 D |
From 54.00€
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PF-04859989 HCl
Item number: TGM-T28368-100mg
Description: PF-04859989 HCl is a brain-penetrable and irreversible inhibitor of kynurenine amino transferase II (KAT II), which is the enzyme responsible for most of the brain synthesis of kynurenic acid. Target: Others. Smiles: Cl.N[C@H]1Cc2ccccc2N(O)C1=O. References: Nematollahi A, Sun G, Jayawickrama GS,...
| Keywords: | PF04859989, PF 04859989, PF-04859989, PF-04859989HCl |
| Application: | KAT II (kynurenine aminotransferase II) inhibitor |
| CAS | 177943-33-8 |
| MW: | 214.65 D |
From 37.00€
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