Description: 1. Neoruscogenin represents a universal pharmacological tool for RORalpha research due to its specific selectivity profile versus other nuclear receptors. Target: ROR. Smiles: [H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)C[C@@H](O)[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CCC(=C)CO1)O2....

Neoruscogenin is a natural sapogenin isolated from Butcher's broom (R. rhizoma), which is traditionally used against chronic venous disorders. It is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORalpha (EC50 = 110 nM). In mice, neoruscogenin up-regulates the expression of several...