Cerulenin is a fungal metabolite originally isolated from C. caerulens that has diverse biological activities. It is active against a variety of bacteria, including B. subtilis, E. coli, B. megaterium, and B. anthracis (MICs = 12.5, 12.5, 50, and 50 µg/ml, respectively) and fungi, including strains of C. albicans,...

White to off-white solid. Soluble in DMSO (25mg/ml), ethanol (20mg/ml) or DMF (25mg/ml). Chemical. CAS: 17397-89-6. Formula: C12H17NO3. MW: 223.3. Isolated from Cephalosporium caerulens. Antibiotic and antifungal compound. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation...

Cerulenin is a noncompetitive inhibitor of fatty acid synthase and induces apoptosis in tumor cell lines.

Cerulenin is an epoxy fatty acid amide isolated from the fungus Cephalosporium caerulens and identified as an antifungal in the 1960s. Over the past 40 years cerulenin has found broad application in lipid biochemistry as an inhibitor fatty acid and sterol biosynthesis. Cerulenin binds to B-keto-acyl-ACP synthase...