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Item number: Cay44116-1

Donitriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D. It inhibits forskolin-induced cAMP formation in C6 cells expressing the human receptors (pD2 = 8.91 and 9.57, respectively). Donitriptan is selective for 5-HT1B and 5-HT1D (Kis = 0.36 and 0.15 nM, respectively, for the human...

Keywords:	F 11356, 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]-benzonitrile, monohydrochloride
Application:	5-HT1B / 5-HT1D agonist
CAS	170911-68-9
MW:	439,94 D

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Donitriptan hydrochloride

Item number: TGM-T21666-100mg

Description: Donitriptan hydrochloride (Donitriptan monohydrochloride) is a potent, high efficacy agonist of 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively. Target: 5-HT Receptor. Smiles: Cl.N#CC1=CC=C(C=C1)N2CCN(C(=O)COC=3C=CC=4NC=C(C4C3)CCN)CC2. References: Muñoz-Islas E, et al. Donitriptan, but not...

Keywords:	Donitriptan monohydrochloride, Donitriptan HCl
CAS	170911-68-9
MW:	439.94 D

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