Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline,...

Doxycycline is a synthetic teracycline. Inhibits angiogenesis in a quantitative in vitro assay of angiogenesis. Inhibits proliferation of the human leukemia cell line K562. It reduces lung metastases by inhibiting the secretion and acitivity of marrix metalloproteinases (MMPs).

Description: Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP). Target: Parasite, Antibacterial, MMP, Antibiotic. Smiles: O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c2c(O)cccc12. References: Trajano V C C , Costa K J R , Lanza C R M , et al. Osteogenic...

A broad-spectrum tetracycline antibiotic, inhibits bacterial protein synthesis, selectively inhibits human MMP-8 and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, at 30 µM, can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or...