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BLU-285
Item number: Cay22985-1
BLU-285 is a dual inhibitor of KIT receptor and platelet-derived growth factor receptor alpha (PDGFRalpha) tyrosine kinases with activating loop mutations (IC50s = 0.27 and 0.24 nM for KITD816V and PDGFRalphaD842V, respectively). It is >150-fold selective for KITD816V and PDGFRalphaD842V over a kinase panel at a...
| Keywords: | Avapritinib,... |
| Application: | PDGFR alpha D842V / KIT Exon 17 mutant inhibitor |
| CAS | 1703793-34-3 |
| MW: | 498.6 D |
From 51.00€
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Avapritinib
Item number: TGM-T5109-100mg
Description: Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the...
| Keywords: | BLU-285 |
| Application: | Targets proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1] (KIT, SCFR, CD117) |
| CAS | 1703793-34-3 |
| MW: | 498.56 D |
From 33.00€
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