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THZ531
Item number: Cay26386-1
THZ531 is an inhibitor of cyclin-dependent kinase 12 (Cdk12) and Cdk13 (IC50s = 158 and 69 nM for Cdk12/cyclin K and Cdk13/cyclin K, respectively). It is selective for Cdk12/cyclin K and Cdk13/cyclin K over Cdk9/cyclin T1 and Cdk7/cyclin H/MAT1 (IC50s = 10.5 and 8.5 µM, respectively). THZ531 inhibits proliferation...
| Keywords: | (2E)-N-[4-[[(3R)-3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-1-piperidinyl]carbonyl]phenyl]-4-(dimethylamino)-2-bu... |
| Application: | CDK12 inhibitor, CDK13 inhibitor |
| CAS | 1702809-17-3 |
| MW: | 558.1 D |
From 67.00€
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THZ531
Item number: TGM-T4293-100mg
Description: THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM). Target: CDK. Smiles: CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12. References: Zhang T, et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem...
| Application: | CDK12 inhibitor, CDK13 inhibitor |
| CAS | 1702809-17-3 |
| MW: | 558.07 D |
From 54.00€
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